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Neonatal Infections

Typical Syndrome of Congenital Infection

Feature	Comment
SGA neonatal infections	Causal relationship exist for rubella, CMV, toxoplasmosis
Hepatosplenomegaly Jaundice Chorioretinitis	Reflects microbial invasion and proliferation (not a defect in organogenesis)
Eye defects Cardiac defects	Cause by cell death or chromosomal damage
Microcephaly Hydrocephaly	Consequence of lesions from congenital infection rather than teratogenesis

Signs

Purpura, jaundice, meningoencephalitis

Common to rubella, CMV, HSV, Coxsackie B, T. gondii, T. pallidum

Typical Clinical Manifestations of

Sign Rubella CMV Toxo Syphilis

Hepatosplenomegaly + + + +

Jaundice + + + +

Exanthem - - + ++

Purpura/petechiae + + + +